Laboratoires S.M.B.’s Vitamin D3
The adjuvant of choice against COVID-19

Laboratoires S.M.B.’s Vitamin D3
The adjuvant of choice against COVID-19

What is Cholecalciferol ?

Cholecalciferol, also known as Vitamin D3 is a precursor of the active vitamin D, which is involved in various metabolic processes. It is a secosteroid that is produced by exposure to sunlight or obtained through food. Nevertheless, these physiological intakes are not sufficient to ensure adequate levels of vitamin D in the body and supplementation is mandatory.

What role does Cholecalciferol play in COVID 19 infection ?

Vitamin D3 deficiency is widespread throughout the population and among its symptoms, there is an increased susceptibility to infection, possibly to COVID 19.
It has been shown that the infection level within the population and the mortality rate were strongly associated to the level of vitamin D3

In parallel, Vitamin D has an established effect on the immune system and it has been shown that vitamin D3 supplementation reduces the susceptibility to respiratory tract infections

As a consequence, our Vitamin D3 product is an excellent adjuvant to treatment. It is capable of preventing white blood cells from releasing too many inflammatory cytokines (« Cytokine Storm »)which are responsible for the most severe and lethal cases of COVID 19.

Guidelines :

Joint guidance on vitamin d in the era of covid-19 from the ASBMR, AACE, Endocrine Society, ECTS, NOF, and IOF : clique ici

Communication of the French National Medicine Association (In French and in English): clique ici

Suggested readings :

Autier P, Mullie P, Macacu A, et al. Effect of vitamin D supplementation on non-skeletal disorders: a systematic review of meta-analyses and randomised trials. Lancet Diabetes Endocrinol. 2017;5(12):986-1004.

Daneshkhah A., Agrawal V., Eshein A., Subramanian H., Roy H.K., & Vadim Backman V. The Possible Role of Vitamin D in Suppressing Cytokine Storm and Associated Mortality in COVID-19 Patients. medRxiv. Published 2020 April 8.

Grant, W.B.; Lahore, H.; McDonnell, S.L.; Baggerly, C.A.; French, C.B.; Aliano, J.L.; Bhattoa, H.P. Evidence that Vitamin D Supplementation Could Reduce Risk of Influenza and COVID-19 Infections and Deaths. Nutrients 2020, 12, 988.

Ilie, P.C., Stefanescu, S. & Smith, L. The role of vitamin D in the prevention of coronavirus disease 2019 infection and mortality. Aging Clin Exp Res 32, 1195–1198 (2020).

Jakovac H. COVID-19 and vitamin D-Is there a link and an opportunity for intervention?. Am J Physiol Endocrinol Metab. 2020;318(5):E589.

Laird E, Rhodes J, Kenny RA. Vitamin D and Inflammation: Potential Implications for Severity of Covid-19. Ir Med J. 2020;113(5):81. Published 2020 May 7.

Martineau AR, Jolliffe DA, Hooper RL, et al. Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data. BMJ. 2017;356:i6583. Published 2017 Feb 15.

Panarese, A. and Shahini, E. (2020), Letter: Covid‐19, and vitamin D. Aliment Pharmacol Ther, 51: 993-995. Published 2020 April 12
Rejnmark L, Bislev LS, Cashman KD, et al. Non-skeletal health effects of vitamin D supplementation: A systematic review on findings from meta-analyses summarizing trial data. PLoS One. 2017;12(7):e0180512. Published 2017 Jul 7.

Tian, Y. and Rong, L. (2020), Letter: Covid‐19, and vitamin D. Authors’ reply. Aliment Pharmacol Ther, 51: 995-996. Published 2020 April 14.

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